Red cell ABO incompatibility and production of tumour necrosis factor-alpha

Red cell ABO incompatibility and production of tumour necrosis factor-alpha.

Tumour necrosis factor-alpha (TNF) is a major mediator of diverse pathophysiological events similar to those of haemolytic transfusion reactions (HTR), such as fever, intravascular coagulation and organ failure. However, the possible role of TNF in HTR has not been investigated. We have constructed an in vitro whole blood model of HTR to examine whether TNF may be produced in red cell ABO incom...

Post-transcriptional regulation of tumour necrosis factor alpha production.

Tumour necrosis factor á (TNFá) is a proinflammatory cytokine produced by activated macrophages, lymphocytes and other cells. The production of TNFá is under transcriptional and post-transcriptional control. Post-transcriptional control of TNFá expression is achieved by regulating translational initiation, mRNA stability, and polyadenylation. 7 10 An adenine and uridine (AU)-rich element (ARE) ...

Tumour necrosis factor alpha blockade and the risk of vasculitis.

Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome.

BACKGROUND The adult respiratory distress syndrome (ARDS) may be regarded as an example of an uncontrolled or excessive inflammatory response in which tumour necrosis factor alpha (TNF-alpha) has been proposed to play a central role. Interleukin 10 (IL-10) has been identified as an important regulator of this response. The potential role for IL-10 in this context was investigated by measuring t...

Cachexia and tumour necrosis factor-alpha in cytomegalovirus infection.

Although cachexia is a common feature of cytomegalovirus infection, little is known about its cause. To explore any contributory role that tumour necrosis factor-alpha (TNF) might have the serum concentrations of TNF in eight patients who developed CMV disease after liver transplantation were investigated. All patients exhibited pronounced and long lasting increases in TNF serum concentrations....